36.7% AMS prevalence in Lhasa
Honigman, B., Theis, M.K., Koziol-McLain, J., et al. (1993). Acute mountain sickness in a general tourist population at moderate altitudes. Annals of Internal Medicine, 118(8), 587–592. Cross-referenced with Wu, T. et al. studies on Han and Tibetan populations at 3,658m.
Oxygen availability calculation
Calculated using the standard barometric pressure exponential decay formula: O₂% = 100 × e^(−altitude/7400). This is a well-established atmospheric physics approximation used throughout altitude medicine literature. Accurate to within ±2–3% for practical purposes across typical trekking altitudes.
AMS risk begins at 2,500m
Luks, A.M., McIntosh, S.E., Grissom, C.K., et al. (2010). Wilderness Medical Society Consensus Guidelines for the Prevention and Treatment of Acute Mountain Sickness. Wilderness & Environmental Medicine, 21(2), 146–155. This is the primary clinical reference for AMS risk thresholds used throughout this tool.
Ascent rate guideline — 300–500m per day above 3,000m
Wilderness Medical Society Consensus Guidelines (Luks et al., 2010, above). Corroborated by Bartsch, P., & Swenson, E.R. (2013). Acute high-altitude illnesses. New England Journal of Medicine, 368, 2294–2302.
Acetazolamide (Diamox) as AMS preventative
Sartori, C., Allemann, Y., Duplain, H., et al. (2002). Acetazolamide for prevention of acute mountain sickness: a double-blind, randomised, placebo-controlled trial. BMJ, 325, 1492. Also: Wilderness Medical Society Consensus Guidelines (Luks et al., 2010).
HACE and HAPE as severe altitude illness
Hackett, P.H., & Roach, R.C. (2001). High-altitude illness. New England Journal of Medicine, 345(2), 107–114. This remains one of the most cited overviews of altitude illness in clinical medicine.
Lake Louise Score — the validated clinical diagnostic instrument
Roach, R.C., Bartsch, P., Hackett, P.H., & Oelz, O. (1993). The Lake Louise acute mountain sickness scoring system. In: Sutton, J.R., Houston, C.S., Coates, G. (eds). Hypoxia and Mountain Medicine. Burlington, VT: Queen City Printers, 272–274. Altitude Check is distinct from this validated instrument — it is a pre-travel educational tool, not a diagnostic score.